FRUZAQLA® (fruquintinib) Side Effects

In the FRESCO-2 study, side effects were generally manageable

Most side effects with FRUZAQLA were manageable in FRESCO-2, and most people were able to stay on treatment. “Manageable” means that the side effects are able to be managed by pausing or reducing the dose of FRUZAQLA or stopping treatment.

  • 1 out of 5 people (20%) needed to stop taking FRUZAQLA because of side effects
  • Less than half of people (47%) needed to pause their dose 
  • 1 out of 4 people (24%) needed to reduce their dose 

The most common side effects included:


Voice changes or hoarseness


Stomach-area (abdominal) pain




Weakness, lack of strength and energy, and feeling very tired or sleepy (asthenia)

  • These are not all the possible side effects of FRUZAQLA
  • 38% of people treated with FRUZAQLA had serious side effects
  • The most common serious side effects were severe bleeding (hemorrhage) and a tear in the stomach or intestinal wall (gastrointestinal perforation)

Be sure to tell your care team about any side effects you have.

They may be able to help you find ways to manage them. Your doctor may change your dose of FRUZAQLA. Your doctor may also pause or stop treatment with FRUZAQLA.

Quality of life 

Learn about quality of life with FRUZAQLA.

FRUZAQLA clinical study

Discover the data from a global clinical trial

Helpful resources and support for people with mCRC

Download FRUZAQLA resources made just for you